Boosting has garnered significant interest across both machine learning and statistical communities. Traditional boosting algorithms, designed for fully observed random samples, often struggle with real-world problems, particularly with interval-censored data. This type of data is common in survival analysis and time-to-event studies where exact event times are unobserved but fall within known intervals. Effective handling of such data is crucial in fields like medical research, reliability engineering, and social sciences. In this work, we introduce novel nonparametric boosting methods for regression and classification tasks with interval-censored data. Our approaches leverage censoring unbiased transformations to adjust loss functions and impute transformed responses while maintaining model accuracy. Implemented via functional gradient descent, these methods ensure scalability and adaptability. We rigorously establish their theoretical properties, including optimality and mean squared error trade-offs. Our proposed methods not only offer a robust framework for enhancing predictive accuracy in domains where interval-censored data are common but also complement existing work, expanding the applicability of existing boosting techniques. Empirical studies demonstrate robust performance across various finite-sample scenarios, highlighting the practical utility of our approaches.

We study the problem of subgroup discovery for survival analysis, where the goal is to find an interpretable subset of the data on which a Cox model is highly accurate. Our work is the first to study this particular subgroup problem, for which we make several contributions. Subgroup discovery methods generally require a "quality function" in order to sift through and select the most advantageous subgroups. We first examine why existing natural choices for quality functions are insufficient to solve the subgroup discovery problem for the Cox model. To address the shortcomings of existing metrics, we introduce two technical innovations: the *expected prediction entropy (EPE)*, a novel metric for evaluating survival models which predict a hazard function; and the *conditional rank statistics (CRS)*, a statistical object which quantifies the deviation of an individual point to the distribution of survival times in an existing subgroup. We study the EPE and CRS theoretically and show that they can solve many of the problems with existing metrics. We introduce a total of eight algorithms for the Cox subgroup discovery problem. The main algorithm is able to take advantage of both the EPE and the CRS, allowing us to give theoretical correctness results for this algorithm in a well-specified setting. We evaluate all of the proposed methods empirically on both synthetic and real data. The experiments confirm our theory, showing that our contributions allow for the recovery of a ground-truth subgroup in well-specified cases, as well as leading to better model fit compared to naively fitting the Cox model to the whole dataset in practical settings. Lastly, we conduct a case study on jet engine simulation data from NASA. The discovered subgroups uncover known nonlinearities/homogeneity in the data, and which suggest design choices which have been mirrored in practice.

Survival analysis relies fundamentally on the semi-parametric Cox Proportional Hazards (CoxPH) model and the parametric Accelerated Failure Time (AFT) model. CoxPH assumes constant hazard ratios, often failing to capture real-world dynamics, while traditional AFT models are limited by rigid distributional assumptions. Although deep learning models like DeepAFT address these constraints by improving predictive accuracy and handling censoring, they inherit the significant challenge of black-box interpretability. The recent introduction of CoxKAN demonstrated the successful integration of Kolmogorov-Arnold Networks (KANs), a novel architecture that yields highly accurate and interpretable symbolic representations, within the CoxPH framework. Motivated by the interpretability gains of CoxKAN, we introduce KAN-AFT (Kolmogorov Arnold Network-based AFT), the first framework to apply KANs to the AFT model. Our primary contributions include: (i) a principled AFT-KAN formulation, (ii) robust optimization strategies for right-censored observations (e.g., Buckley-James and IPCW), and (iii) an interpretability pipeline that converts the learned spline functions into closed-form symbolic equations for survival time. Empirical results on multiple datasets confirm that KAN-AFT achieves performance comparable to or better than DeepAFT, while uniquely providing transparent, symbolic models of the survival process.

Designing optimal treatment plans for patients with comorbidities requires accurate cause-specific mortality prognosis. Motivated by the recent availability of linked electronic health records, we develop a nonparametric Bayesian model for survival analysis with competing risks, which can be used for jointly assessing a patient's risk of multiple (competing) adverse outcomes. The model views a patient's survival times with respect to the competing risks as the outputs of a deep multi-task Gaussian process (DMGP), the inputs to which are the patients' covariates. Unlike parametric survival analysis methods based on Cox and Weibull models, our model uses DMGPs to capture complex non-linear interactions between the patients' covariates and cause-specific survival times, thereby learning flexible patient-specific and cause-specific survival curves, all in a data-driven fashion without explicit parametric assumptions on the hazard rates. We propose a variational inference algorithm that is capable of learning the model parameters from time-to-event data while handling right censoring. Experiments on synthetic and real data show that our model outperforms the state-of-the-art survival models.

Designing optimal treatment plans for patients with comorbidities requires accurate cause-specific mortality prognosis. Motivated by the recent availability of linked electronic health records, we develop a nonparametric Bayesian model for survival analysis with competing risks, which can be used for jointly assessing a patient's risk of multiple (competing) adverse outcomes. The model views a patient's survival times with respect to the competing risks as the outputs of a deep multi-task Gaussian process (DMGP), the inputs to which are the patients' covari-ates. Unlike parametric survival analysis methods based on Cox and Weibull models, our model uses DMGPs to capture complex non-linear interactions between the patients' covariates and cause-specific survival times, thereby learning flexible patient-specific and cause-specific survival curves, all in a data-driven fashion without explicit parametric assumptions on the hazard rates. We propose a varia-tional inference algorithm that is capable of learning the model parameters from time-to-event data while handling right censoring. Experiments on synthetic and real data show that our model outperforms the state-of-the-art survival models.

We introduce a semi-parametric Bayesian model for survival analysis.

Survival analysis is critical for cancer prognosis and treatment planning, yet existing methods lack the transparency essential for clinical adoption. While recent pathology agents have demonstrated explainability in diagnostic tasks, they face three limitations for survival prediction: inability to integrate multimodal data, ineffective region-of-interest exploration, and failure to leverage experiential learning from historical cases. We introduce SurvAgent, the first hierarchical chain-of-thought (CoT)-enhanced multi-agent system for multimodal survival prediction. SurvAgent consists of two stages: (1) WSI-Gene CoT-Enhanced Case Bank Construction employs hierarchical analysis through Low-Magnification Screening, Cross-Modal Similarity-Aware Patch Mining, and Confidence-Aware Patch Mining for pathology images, while Gene-Stratified analysis processes six functional gene categories. Both generate structured reports with CoT reasoning, storing complete analytical processes for experiential learning. (2) Dichotomy-Based Multi-Expert Agent Inference retrieves similar cases via RAG and integrates multimodal reports with expert predictions through progressive interval refinement. Extensive experiments on five TCGA cohorts demonstrate SurvAgent's superority over conventional methods, proprietary MLLMs, and medical agents, establishing a new paradigm for explainable AI-driven survival prediction in precision oncology.

Apart from modeling the time to event, in the presence of competing risks, it is also important to model the event type, or under which risk the event is likely to occur first. Though one can censor subjects with an occurrence of the event under a competing risk other than the risk of special interest, so that every survival model that can handle censoring is able to model competing risks, it is problematic to violate the principle of non-informative censoring [18, 19].

"Universalization"-based reasoning, a theory of moral thinking, are able to achieve

Apart from modeling the time to event, in the presence of competing risks, it is also important to model the event type, or under which risk the event is likely to occur first. Though one can censor subjects with an occurrence of the event under a competing risk other than the risk of special interest, so that every survival model that can handle censoring is able to model competing risks, it is problematic to violate the principle of non-informative censoring [18, 19].